Volume 13, Issue 4, April, 2026

Review Articles
1

Juan Carlos Rojas Chaves, Ronald Heriberto Flores Araya, Jimena Maria Hidalgo Retana, Maria Rebeca Sanchez Calderon, Oscar Rosales Chaves, Esther Barrantes Gonzalez.

Severe Acute Pancreatitis: Integrated Pathophysiology and Evidence-Based Clinical Management.

Int. Arch. Integr. Med., 2026; 13(4): 1-16.

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DOI: 10.5281/zenodo.19809202

https://doi.org/10.5281/zenodo.19809202

2

Ronald Heriberto Flores Araya, Antony Freizer Tenorio Fallas, Jimena Maria Hidalgo Retana, Angelica Dayanna Rodriguez Luna, Zianny Pamela Gonzalez Benavides, Kevin Vargas Tenorio.

Celiac Disease with Systemic Extraintestinal Manifestations: Pathophysiological Mechanisms, Comprehensive Diagnostic Approach, and Integrated Therapeutic Management.

Int. Arch. Integr. Med., 2026; 13(4): 17-31.

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DOI: 10.5281/zenodo.19809363

https://doi.org/10.5281/zenodo.19809363

3

Manuel Alejandro Ramirez Solano, Jimena Maria Hidalgo Retana, Antony Freizer Tenorio Fallas, Mariana Bolanos Castro, Kristian Lewis Thomas, Lola Dive Chagnon.

Hypopharyngeal and Cervical Esophageal Carcinoma: Diagnostic and Therapeutic Approach.

Int. Arch. Integr. Med., 2026; 13(4): 32-48.

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DOI: 10.5281/zenodo.19809499

https://doi.org/10.5281/zenodo.19809499

4

Ricardo Telles Vega, Tracy Paola Perez Herrera, Maria Fernanda Fernandez Mora, Diana Gonzalez Murillo, Nicole Chaves Torres.

Hospital-Acquired Bacterial Pneumonia: Updated Strategies for Intravenous Antibiotic Coverage.

Int. Arch. Integr. Med., 2026; 13(4): 49-63.

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DOI: 10.5281/zenodo.19809676

https://doi.org/10.5281/zenodo.19809676

5

Nicolas Arce Vargas, Alin Pereira Moreno, Natalia Prendas Navarro, Maria Jesus Rojas Leiton, Diego Salom Soto, Monica Solis Chan.

Acute Intoxication with Tricyclic Antidepressants and Selective Serotonin Reuptake Inhibitors: Pathophysiology, Clinical Spectrum, and Evidence-Based Emergency Management.

Int. Arch. Integr. Med., 2026; 13(4): 64-77.

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DOI: 10.5281/zenodo.19809903

https://doi.org/10.5281/zenodo.19809903

6

Gabriel Munoz Jackson, Ivonne Consumi Flores, Maria Jose Solis Marin, Alexandra Mora Quiros, Isis Karolina Vega Vega, Mariana Bolanos Castro.

Neuropathic Pain: Pharmacological Management with Emphasis on Anesthetic Agents and Neuromodulatory Therapies.

Int. Arch. Integr. Med., 2026; 13(4): 78-93.

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DOI: 10.5281/zenodo.19810138

https://doi.org/10.5281/zenodo.19810138

7

Alejandro Ismael Pena Montenegro, Natyeli de los Angeles Murillo Brenes, Marcela Valeria Rodriguez Solano, Montserrath Quiros Chinchilla, Bryan Gonzalez Madrigal, Maria Luisa Madrigal Mora.

Comprehensive Management of Metabolic Syndrome in Older Adults: Clinical and Preventive Implications.

Int. Arch. Integr. Med., 2026; 13(4): 94-108.

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DOI: 10.5281/zenodo.19810309

https://doi.org/10.5281/zenodo.19810309

8

David Daniel Diaz Polo, Fernando Roman Sing, Victor Fuenmayor Macrobio, Bary Gentilini Espinoza, Mariel Quiros Arroyo.

Postoperative Dyspnea: Most Frequent Etiologies, Initial Evaluation, and Early Clinical Management.

Int. Arch. Integr. Med., 2026; 13(4): 109-123.

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DOI: 10.5281/zenodo.19810517

https://doi.org/10.5281/zenodo.19810517

9

Dario Guzman Gutierrez, Ariadna Nicole Bonilla Aguilar.

Acquired Arteriovenous Fistulas: A Comprehensive Review of Etiology, Anatomical Distribution, Pathophysiology, Clinical Presentation, Diagnosis, and Management.

Int. Arch. Integr. Med., 2026; 13(4): 124-137.

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DOI: 10.5281/zenodo.19810748

https://doi.org/10.5281/zenodo.19810748

10

Edgardo Jose Soto Junco, Ekaterina Daniela Hernandez Baker, Nathalie Rodriguez Herrera, Mariela Michell Matamoros Cordoba, Allan Mauricio Castro Sibaja, Ricardo Arturo Vargas Fernandez.

Management of Depressive Episodes in Bipolar Disorder: Clinical Risks, Evidence Gaps, and Strategic Use of Antidepressants.

Int. Arch. Integr. Med., 2026; 13(4): 138-153.

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DOI: 10.5281/zenodo.19810957

https://doi.org/10.5281/zenodo.19810957

11

Carolina Barrientos Hernandez, Mariana Bolanos Castro, Oscar Rosales Chaves, Kristian Lewis Thomas, Ricardo Montero Zamora, Fernando Rodriguez Flores.

Acute cholecystitis grade IIIII: Early cholecystectomy vs percutaneous drainage.

Int. Arch. Integr. Med., 2026; 13(4): 154-167.

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DOI: 10.5281/zenodo.19813209

https://doi.org/10.5281/zenodo.19813209

12

Carmen Andrea Soto Rojas, Diana Patricia Vargas Viquez, Maria Jose Viquez Angulo, Otto Andres Acuna Lopez, Esther Barrantes Gonzalez, Juan Manuel Boffill De Leon.

Conservative versus Surgical Management of Partial Rotator Cuff Tears: Current Evidence, Clinical Outcomes, and Selection Criteria.

Int. Arch. Integr. Med., 2026; 13(4): 168-181.

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DOI: 10.5281/zenodo.19813406

https://doi.org/10.5281/zenodo.19813406

13

Karina de Los Angeles Montero Salazar, Maria Gabriela Arroyo Salas, Maria Jose Viquez Angulo, Katherin Duran Chavarria, Maria Celeste Leiton Duran, Oscar Zuniga Vargas.

Noninvasive Ventilation in Preterm Neonates: Impact on the Incidence and Outcomes of Bronchopulmonary Dysplasia.

Int. Arch. Integr. Med., 2026; 13(4): 182-196.

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DOI: 10.5281/zenodo.19813628

https://doi.org/10.5281/zenodo.19813628

14

Divya Donepudi, Gunvanti Rathod, Pragnesh Parmar.

Artificial Intelligence and Generative AI in Digital Pathology: Current Advancements, Clinical Applications, and Challenges in Global and Resource-Limited Settings.

Int. Arch. Integr. Med., 2026; 13(4): 197-203.

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DOI: 10.5281/zenodo.19813798

https://doi.org/10.5281/zenodo.19813798

15

Susan Quiros Montero, Maria Gabriela Fallas Gomez, Delma Veronica Ruiz Garcia, Yariela Sileny Jimenez Vargas, Sofia Soto Corrales.

Initial Management of the Anticoagulated Patient with Upper Gastrointestinal Bleeding in the Emergency Department.

Int. Arch. Integr. Med., 2026; 13(4): 204-217.

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DOI: 10.5281/zenodo.19815994

https://doi.org/10.5281/zenodo.19815994

16

Joshua Granados Apu, Maria Rebeca Sanchez Calderon, Maria Paula Alfaro Murillo, Maria Alejandra Ocampo Viquez, Maria Isabella Trejos Chiulli, Otto Andres Acuna Lopez.

Thromboembolism in Pregnancy: A Comprehensive Risk-Based Diagnostic and Therapeutic Approach.

Int. Arch. Integr. Med., 2026; 13(4): 218-232.

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DOI: 10.5281/zenodo.19816193

https://doi.org/10.5281/zenodo.19816193

17

David Daniel Diaz Polo, Fernando Roman Sing, Victor Fuenmayor Macrobio, Bary Gentilini Espinoza, Mariel Quiros Arroyo, Eric Umana Miranda.

Micro-surgical Clipping versus Endovascular Therapy in Middle Cerebral Artery Aneurysms: Indications, Outcomes, and Contemporary Clinical Considerations.

Int. Arch. Integr. Med., 2026; 13(4): 233-246.

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DOI: 10.5281/zenodo.19816397

https://doi.org/10.5281/zenodo.19816397

18

Carlos Manuel Venegas Valverde, Byron Steven Drummond Artavia, Luis Carlo Peralta Quesada, Steven Miguel Segura Angulo, Jeaustin Javier Matarrita Angulo.

Diagnostic and Therapeutic Approach to Abnormal Uterine Bleeding in Women Using Etonogestrel Subdermal Implants.

Int. Arch. Integr. Med., 2026; 13(4): 247-258.

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DOI: 10.5281/zenodo.19816613

https://doi.org/10.5281/zenodo.19816613

19

Montserrat Sthepania Martinez Rodas, Andrea Retana Gonzalez, Hector Gabriel Torres Garcia, Addy Samantha Defrancisco Aguero, Ana Karen Blanco Salazar, Nicole Alejandra Chaves Ortega.

Neuropsychiatric Manifestations Following Traumatic Brain Injury: Clinical Implications for Comprehensive Patient Care.

Int. Arch. Integr. Med., 2026; 13(4): 259-270.

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DOI: 10.5281/zenodo.19816830

https://doi.org/10.5281/zenodo.19816830

20

Sofia Segreda Castro, Maria Paula Alfaro Murillo, Zianny Pamela Gonzalez Benavides, Maria Alejandra Ocampo Viquez, Kevin Jose Salazar Lopez, Ricardo Arturo Vargas Fernandez.

Vaginal Microbiome and Pelvic Inflammatory Disease: Integrated Pathophysiological Mechanisms and Clinical Implications.

Int. Arch. Integr. Med., 2026; 13(4): 271-285.

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DOI: 10.5281/zenodo.19817082

https://doi.org/10.5281/zenodo.19817082

21

Maria Lisandra Esquivel Porras, Maria Gabriela Arroyo Salas, Maria Paula Alfaro Murillo, Maria Alejandra Ocampo Viquez, Sofia Segreda Castro, Enmanuel Jose Morales Delgado.

Deep Infiltrating Endometriosis: Magnetic Resonance Imaging Diagnosis and Surgical Correlation.

Int. Arch. Integr. Med., 2026; 13(4): 286-299.

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DOI: 10.5281/zenodo.19818848

https://doi.org/10.5281/zenodo.19818848

22

Manuel Alejandro Ramirez Solano, Maria Lisandra Esquivel Porras, Maria Orozco Arguedas, Mariana Bolanos Castro, Kristian Lewis Thomas, Ricardo Montero Zamora.

Clinical Management of Pancreatic Intraductal Papillary Mucinous Neoplasms: Practical Application of the Fukuoka Criteria in Risk Stratification and Treatment Decision-Making.

Int. Arch. Integr. Med., 2026; 13(4): 300-316.

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DOI: 10.5281/zenodo.19819922

https://doi.org/10.5281/zenodo.19819922

23

Melina Mata Serrano, Cristian Ismael Gomez Saborio, Isis Karolina Vega Vega, Maria Celeste Leiton Duran, Yakira Delgado Angulo, Ricardo Montero Zamora.

Anesthetic Strategies to Minimize Complications Associated with Cardiopulmonary Bypass Time in Cardiac Surgery.

Int. Arch. Integr. Med., 2026; 13(4): 317-336.

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DOI: 10.5281/zenodo.19820220

https://doi.org/10.5281/zenodo.19820220

24

Nicole Chaves Torres, Ricardo Telles Vega, Tracy Paola Perez Herrera, Maria Fernanda Fernandez Mora, Diana Gonzalez Murillo.

Unexplained Postoperative Cyanosis: Local AnestheticInduced Methemoglobinemia, Diagnosis and Clinical Management.

Int. Arch. Integr. Med., 2026; 13(4): 337-348.

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DOI: 10.5281/zenodo.19820495

https://doi.org/10.5281/zenodo.19820495

25

Pragnesh Parmar, Gunvanti Rathod.

Strengthening Tertiary Healthcare in India: The Role of the Pradhan Mantri Swasthya Suraksha Yojana (PMSSY).

Int. Arch. Integr. Med., 2026; 13(4): 349-355.

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DOI: 10.5281/zenodo.19849105

https://doi.org/10.5281/zenodo.19849105

26

Daniel Navarro Morales, Alvaro Calvo Mondragon, Katherine Maroto Monge, Fabiola Alvarez Mora, Heizel Trejos Quiros.

Molecular Pathology of Colorectal Cancer: Genetic Alterations, Signaling Pathways, and Clinical Implication.

Int. Arch. Integr. Med., 2026; 13(4): 356-371.

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DOI: 10.5281/zenodo.19820894

https://doi.org/10.5281/zenodo.19820894

27

Daniel Navarro Morales, Alvaro Calvo Mondragon, Katherine Maroto Monge, Fabiola Alvarez Mora, Heizel Trejos Quiros.

Anesthetic Management in Elderly Patients: Physiological Changes, Pharmacological Adjustments, Postoperative Delirium, and Strategies for Safe Perioperative Care.

Int. Arch. Integr. Med., 2026; 13(4): 372-387.

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DOI: 10.5281/zenodo.19821871

https://doi.org/10.5281/zenodo.19821871

Original Research Article

28

Anas Abdul Khader.

Interoperator Variations in Interpretation of Cone Beam Computed Tomography for Dental Implant Treatment Planning: A Retrospective Observational Study.

Int. Arch. Integr. Med., 2026; 13(4): 388-401.

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DOI: 10.5281/zenodo.19822247

https://doi.org/10.5281/zenodo.19822247

Review Articles

29

Andrea Pamela Gonzalez Quesada, Grethel Acuna Sanchez, Estefany Gomez Lopez, Melanny Delgado Benitez, Bernal Esteban Chavarria Munoz, Natividad Ana Garcia Arredondo.

Prevalence of Extended-Spectrum Beta-Lactamase-Producing Enterobacterales in Urinary Tract Infections and Its Impact on Antimicrobial Therapeutic Selection.

Int. Arch. Integr. Med., 2026; 13(4): 402-417.

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DOI: 10.5281/zenodo.19822532

https://doi.org/10.5281/zenodo.19822532

30

Carmen Andrea Soto Rojas, Diana Patricia Vargas Viquez, Maria Daniela Gonzalez Mejias, Otto Andres Acuna Lopez, Kevin Jose Salazar Lopez, Nicole Maria Matias Saborio.

Chronic Ankle Instability and Associated Osteochondral Lesions: Pathophysiological Interplay, Advanced Diagnostic Approaches, and Contemporary Therapeutic Strategies.

Int. Arch. Integr. Med., 2026; 13(4): 418-433.

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DOI: 10.5281/zenodo.19822757

https://doi.org/10.5281/zenodo.19822757

31

Josue Campos Chinchilla, Juan Carlos Rojas Chaves, Miguel Caled Trejos Roman, Ariel Jose Jimenez Lopez, Luis Enrique Vasquez Villalobos, Jose Pablo Rosales Jimenez.

Rotational Atherectomy (Rotablator) in Complex Calcified Coronary Lesions: Current Evidence and Clinical Applications.

Int. Arch. Integr. Med., 2026; 13(4): 434-446.

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DOI: 10.5281/zenodo.19843816

https://doi.org/10.5281/zenodo.19843816

32

Josue Campos Chinchilla, Miguel Caled Trejos Roman, Yoysi Leilani Duarte Molina, Ariel Jose Jimenez Lopez, Maria Celeste Leiton Duran, Katherine Maria Blandon Carmona.

Frailty and Surgery: Impact on Surgical and Anesthetic Outcomes.

Int. Arch. Integr. Med., 2026; 13(4): 447-460.

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DOI: 10.5281/zenodo.19843996

https://doi.org/10.5281/zenodo.19843996

33

Carlos Manuel Venegas Valverde, Byron Steven Drummond Artavia, Luis Carlo Peralta Quesada, Steven Miguel Segura Angulo, Jeaustin Javier Matarrita Angulo.

Glucagon-Like Peptide-1 Receptor Agonists Beyond Diabetes Mellitus: Pathophysiological Foundations and Clinical Applications in Obesity, Heart Failure, Chronic Kidney Disease, and Hepatic Steatosis.

Int. Arch. Integr. Med., 2026; 13(4): 461-476.

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DOI: 10.5281/zenodo.19849378

https://doi.org/10.5281/zenodo.19849378